NanoCuvette™ S

Efficient Particle Sizing and Concentrations

Next-gen Scattering Analysis

The NanoCuvette™ S allows for spectrophotometric quantification of particle/cell size and concentration analysis in numerous industries such as biotechnology, pharmaceuticals, life science, foods, including various industrial applications for quality control.

The capacity of NanoCuvette™ S goes far beyond any product currently on the market in terms of achieving easy, fast, and reliable particle/cell size analysis and concentration determination. With the NanoCuvette™ S you have the functionality to determine small particles down to 50 nm, while simultaneously quantify their concentration.

 

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Expanding Capabilities

The NanoCuvette™ S expands the capabilities of your spectrophotometer and allows you to perform combined angle-resolved light scattering and absorbance at 190-1100 nm. Integrated in the surface is a patented photonic nanocrystal (optical filter), that register light scattering such that it measures particle sizes near the photonic crystal surface.

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Why Upgrade to NanoCuvette™ S? 

Traditionally, spectrophotometry laboratory work has been limited by lack of robust methods to determine size and concentrations. We upgrade UV-Vis spectrophotometry around the world and across all major instrument brands to create new ways to determine particle size analysis, perfom refractive index measurements in a label-free, fast, cheap, and reliable method.

Technology: How we do it

Absorption versus label-free spectroscopy

With absorption spectroscopy, the Beer–Lambert law relates the attenuation of light to the properties of the material through which the light is traveling:

A = εcl + A0 ,

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where A is the absorbance, ε is molar extinction coefficient, c is the concentration, l is the path length and A0 is the background absorbance.

Lambert, J.H. (1760). Photometria sive de mensura et gradibus luminis, colorum et umbrae [Photometry, or, On the measure and gradations of light intensity, colors, and shade] (in Latin). Augsburg, (Germany): Eberhardt Klett.
Beer (1852). "Bestimmung der Absorption des rothen Lichts in farbigen Flüssigkeiten" [Determination of the absorption of red light in colored liquids]. Annalen der Physik und Chemie (in German). 162 (5): 78–88. Bibcode:1852AnP...162...78B. doi:10.1002/andp.1852162050

In contrast, when light hits a nanoscale photonic crystal, the resonance wavelength is related to the refractive index or concentration close to the surface:

λ = β(αc + ns) + λ0 ,

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where λ is the wavelength, β is a coefficient, α is the specific refractive increment, c is the concentration, ns is the solvent refractive index and λ0 is the reference resonance wavelength. This is called label-free spectroscopy

Nano Lett. 2014, 14, 8, 4499–4504Publication Date:July 8, 2014https://doi.org/10.1021/nl5014986Copyright © 2014 American Chemical Society.
Højlund-Nielsen, E., Clausen, J., Mäkela, T., Thamdrup, L. H., Zalkovskij, M., Nielsen, T., Pira, N. L., Ahopelto, J., Mortensen, N. A., Kristensen, A. (2016). Plasmonic Colors: Toward Mass Production of Metasurfaces. Adv. Mater. Technol., 1: 1600054. doi: 10.1002/admt.201600054

Particle Sizing and Concentrations in the Palm of Your Hand.

Key Uses

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  • Label-free measurements at different volumes (100 μL - 200 μL)

  • Size analysis of particles from 50 nm to 3000 nm with concentration detection limit of 0,0001% to 0,1%

  • Surface refractive index range measurements at 1.0 - 1.6 nD

  • Turbidity and impurity QC- measurements

Want NanoCuvette™ S or a Demo? 

Lab-work has never been easier.

User Centric Experience

With NanoCuvette™ S particles can be quantified in minutes with enhanced sensitivity, reliability, and reproducibility. It measures concentrations and sizes in a standard spectrophotometer without expensive specialized instrument. Together with the unique user-centric online software SpectroWorks™ it automatically analyses the results in minutes. 

Furthermore, NanoCuvette™ S have the free ”Basic cuvette” spectrum file functionality in SpectroWorks™, which you can use for automatic standard curve processing by using our free report template in our Colab Notebook.

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Static Light Scattering and Cloud Computing

Particle can be measured since light scattering depends on angle and wavelength. NanoCuvette™ S utilizes Rayleigh and Mie scattering at any given time to precisely determine the sizes in the dispersion of both large and small particles. SpectroWorks™ use the scattered light to model the size and concentration within the sample using more than 500 million light simulations.

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Superior technology with no up-front cost or training for your lab

Key Features.

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Supports Major Brands

Improved and affordable upgrade for your existing UV-Vis spectrophotometer. Also allows basic cuvette measurements.

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Designed For Humans

Easy to use with no special training required. Online support included.

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Accurate and Instant Results

Results are calculated based on spectral analysis. Our engine in SpectroWorks™ is fast and makes it a breeze to extract results. 

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Unique Traceability

Made in Denmark with unique ID for traceability and access to online calibration data.

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Semi-reusable cuvettes

The NanoCuvettes™ can be re-used up to a certain amount depending on application and maintenance.

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Less sample needed for analysis
Measurements at different volumes between 100μL and 200μL

Upgrade your UV-Vis spectrophotometer to do Particle Size and Concentration Analysis.

Ready to get NanoCuvette™ S ?

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*Purchasing NanoCuvette™ S at reseller includes life-time access, data storage and upgrades to SpectroWorks™, free support and  individual calibration for best performance. Price per measurement may vary depending on sample and use.

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Your expert in UV-Vis technology

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